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SCO2 Antibody

CAT: 0223-4045-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4045-01Size:0.02 mg
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Background
SCO2 Antibody: Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
NCBI Gene ID
9997
Swiss Prot
O43819
Accession Number
O43819
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
SCO2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1209 - HL60 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (84%), Bovine: (84%)
Buffer
SCO2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SCO2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SCO2
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Cytochrome c oxidase assembly protein
NCBI Organism
Homo sapiens
Background Reference 01
Glerum DM, Shtanko A, and Tzagoloff A. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J. Biol. Chem. 1996; 271:20531-5.
Background Reference 02
Horng Y-C, Leary SC, Cobine PA, et al. Human Sco1 and Sco2 function as copper-binding proteins. J. Biol. Chem. 2005; 280:34113-22.
Background Reference 03
Matoba S, Kang J-G, Patino WD, et al. p53 regulates mitochondrial respiration. Science 2006; 312:1650-3.
Background Reference 04
Papadopoulou LC, Sue CM, Davidson MM, et al. Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. Nat. Genetics 1999; 23:333-7.
Other Product Names
SCO2 Antibody: SCOD1, Protein SCO2 homolog, mitochondrial
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
8134662
Physical Properties
Liquid

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