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BANF1 Antibody

CAT: 0223-4019-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4019-01Size:0.02 mg
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Background
BANF1 Antibody: Barrier-to-autointegration factor 1 (BANF1) is a conserved chromatin protein that non-specifically binds double-stranded DNA. BAF also interacts with a family of nuclear proteins that include LAP2, emerin, and MAN1. It is also a host cell component of retroviral pre-integration complexes (PICs), including that of HIV. BAF will bind to p55 Gag (the structural precursor of HIV-1 virions) as well as its cleaved product matrix. In addition to being a host cell component of the PIC, it is thought that BAF is also present at low levels in incoming virions, and thus might contribute to the assembly or activity of HIV-1 PICs through direct binding to matrix as well as DNA.
NCBI Gene ID
8815
Swiss Prot
O75531
Accession Number
AAH05942
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4019
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar BANF1 expression profile in human and mouse cell lines detected by two independent anti-BANF1 antibodies that recognize different epitopes, 4017 against C-terminus domain and 4019 against N-terminus domain. BANF1 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4017 4019
Field of Research
Infectious Disease
Purification
BANF1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
BANF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BANF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human BANF1 has one isoform (89aa, 10kD) . Mouse BANF1 has one isoform (89aa, 10kD) and Rat BANF1 also has one isoform (89aa, 10kD) . 4019 can detect human, mouse and rat.
Symbol
BANF1
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Barrier to autointegration factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Furukawa. J. Cell Sci. 1999; 112:2485-92.
Background Reference 02
Cai et al. EMBO J. 2001; 20:4399-407.
Background Reference 03
Chen and Engelman. Proc. Natl. Acad. Sci. USA 1998; 95:15270-4.
Other Product Names
BANF1 Antibody: BAF, NGPS, BCRP1, D14S1460, BAF, BCRG1, Barrier-to-autointegration factor, Breakpoint cluster region protein 1
Tested Applications
ELISA, WB, IF
Protein ID
13543577
Physical Properties
Liquid

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