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RIG-1 Antibody

CAT: 0223-3953-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3953-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RIG-1 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKε through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
NCBI Gene ID
23586
Swiss Prot
O95786
Accession Number
O95786
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
RIG-1 antibody was raised against human GST-tagged RIG-1 protein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
RIG-1 Antibody is Protein A purified.
Positive Control
Cat. No. 1285 - C2C12 Cell Lysate
Concentration
1 mg/mL
Buffer
RIG-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RIG-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
DDX58
Positive Control 2
Cat. No. 1301 - Human Heart Tissue Lysate
Positive Control 3
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
NCBI Organism
Homo sapiens
Background Reference 01
Akira S, Uematsu S, and Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801.
Background Reference 02
Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004; 5:730-7.
Background Reference 03
Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413:732-8.
Background Reference 04
Sharma S, tenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300:1148-51.
Other Product Names
RIG-1 Antibody: RIGI, RIG-I, RLR-1, Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58
Tested Applications
ELISA, WB, IHC-P
Protein ID
81170421
Physical Properties
Liquid

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