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UNG1 Antibody

CAT: 0223-3863-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3863-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.
NCBI Gene ID
7374
Swiss Prot
P13051
Accession Number
NP_003353
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
3863
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar UNG1 expression profile in human cell lines detected by two independent anti-UNG1 antibodies that recognize different epitopes, 3863 against C-terminus domain and 3865 against central domain. UNG1 proteins are detected in all tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3863 3865
Field of Research
Neuroscience, Infectious Disease
Purification
UNG1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1285 - C2C12 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat (85%) .
Buffer
UNG1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
UNG1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human UNG1 has 2 isoforms, including isoform 1 (304aa, 34kD) and isoform 2 (313aa, 35kD) . Mouse UNG1 has 2 isoforms, including isoform 1 (295aa, 33kD) and isoform 2 (306aa, 34kD) . Rat UNG1 has one isoform (303aa, 34kD) . 3863 can detect human, mouse and rat.
Symbol
UNG
Positive Control 2
Cat. No. 1301 - Human Heart Tissue Lysate
Positive Control 3
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
Uracil-DNA glycosylase
NCBI Organism
Homo sapiens
Background Reference 01
Krokan et al. Prog. Nucleic Acid Res. Mol. Biol. 2001; 68:365-86.
Background Reference 02
Fromm and Verdine. Adv. Protein Chem. 2004; 69:1-41.
Background Reference 03
Kachhap and Singh. Mol. Cancer 2004; 3:32.
Background Reference 04
Imam et al. Neurobiol. Aging 2006; 27:1129-36.
Other Product Names
UNG1 Antibody: DGU, UDG, UNG1, UNG2, HIGM4, HIGM5, UNG15, DGU, Uracil-DNA glycosylase
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
6224979
Physical Properties
Liquid

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