TOLLIP Antibody

• Background:

  TOLLIP Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.

• NCBI Gene ID:

  54472

• Swiss Prot:

  Q9H0E2

• Accession Number:

  AAH18272

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  TOLLIP Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken: (94%), Bovine: (88%)

• Buffer:

  TOLLIP Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TOLLIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TOLLIP

• Positive Control 2:

  Cat. No. 1208 - THP-1 Cell Lysate

• Positive Control 3:

  Cat. No. 17-008 - THP-1 Cell Slide

• NCBI Official Name:

  Toll interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol.2003; 21:335-76.

• Background Reference 02:

  Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol.2002; 20:197-216.

• Background Reference 03:

  McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol. Imm.2004; 41:577-82.

• Background Reference 04:

  Zhang G and Ghosh S. Negative regulation of Toll-like receptor-mediated signaling by Tollip. J. Biol. Chem.2002; 277:7059-65.

• Other Product Names:

  TOLLIP Antibody: IL-1RAcPIP, Toll-interacting protein

• Tested Applications:

  ELISA, WB, IHC-P, ICC, IF

• Protein ID:

  17390641

• Physical Properties:

  Liquid