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CRMP1 Antibody

CAT: 0223-3625-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3625-01Size:0.02 mg
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Background
CRMP1 Antibody: Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
NCBI Gene ID
1400
Swiss Prot
Q14194
Accession Number
AAH07613
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Neuroscience
Purification
CRMP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1223 - Caco-2 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%), Chicken: (93%)
Buffer
CRMP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CRMP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CRMP1
Positive Control 2
Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 3
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Collapsin response mediator protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Charrier E, Reibel S, Rogemond V, et al. Collapsin response mediator proteins (CRMPs) : involvement in nervous system development and adult neurodegenerative disorders. Mol. Neurobiol. 2003; 28:51-64.
Background Reference 02
Cameron HA and McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus.J. Comp. Neurol. 2001; 435:406-417.
Background Reference 03
Hamajima N, Matsuda K, Sakata S, et al. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996; 180:157-63.
Background Reference 04
Quach TT, Duchemin A-M, Rogemond V, et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol. Cell. Neurosci. 2004; 25:433-43.
Other Product Names
CRMP1 Antibody: DRP1, DRP-1, CRMP-1, DPYSL1, ULIP-3, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14043246
Physical Properties
Liquid

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