Bit1 Antibody

CAT: 0223-3603-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3603-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Bit1 Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apoptosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE. Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
NCBI Gene ID
51651
Swiss Prot
Q9Y3E5
Accession Number
NP_057161
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
Bit1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
Bit1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Bit1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PTRH2
Positive Control 2
Cat. No. 1212 - 3T3 Cell Lysate
Positive Control 3
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
Peptidyl-tRNA hydrolase 2
NCBI Organism
Homo sapiens
Background Reference 01
Martin SS and Vuori K. Regulation of Bcl-2 proteins during anoikis and amorphosis. Biochim Biophys Acta. 2004; 1692:145-57.
Other Product Names
Bit1 Antibody: BIT1, PTH2, CGI-147, BIT1, Peptidyl-tRNA hydrolase 2, mitochondrial, Bcl-2 inhibitor of transcription 1, PTH 2
Tested Applications
ELISA, WB, ICC, IF
Protein ID
7706351
Physical Properties
Liquid

Related Products

CatalogName
3603PBit1 Peptide
3605PBit1 Peptide
31-397BiTE Format Isotype Control for Bispecific Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
63-408DGKB Antibody
63-412AK5 Antibody
63-420HK3 Antibody
63-422HK2 Antibody

Alternative Products

CatalogName
MBS151489-01Bit1 Antibody
APG02277GPolyclonal Bit1 Antibody
MBS9214490-01Bit1 Antibody (Center)
A02459Anti-Bit1 PTRH2 Antibody
ER2001-71Bit1 Rabbit Polyclonal Antibody
OAAB09547-400ULBit1 Antibody - middle region
MBS9219777-01Bit1 Antibody (Center) Blocking Peptide
AMR09656GPolyclonal PTRH2 / BIT1 Antibody (N-Terminus)
MBS3905365-01Rabbit anti-PTRH2/BIT1 Antibody, Affinity Purified
MBS153130-01Bit1 Peptide

Popular Products