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NGFR Antibody

CAT: 0223-3593-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3593-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NGFR Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κ B and various mitogen-activated protein kinases. Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family. Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4. NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins. Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR.
NCBI Gene ID
4804
Swiss Prot
P08138
Accession Number
NP_002498
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
NGFR antibody was raised against purified recombinant human NGFR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Growth Factors
Purification
NGFR Antibody is Protein A purified.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
NGFR Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NGFR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NGFR
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Nerve growth factor receptor (TNFR superfamily, member 16)
NCBI Organism
Homo sapiens
Background Reference 01
Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.
Background Reference 02
Johnson D, Lanahon A, Buck CR, et al. Expression and structure of the human NGF receptor. Cell 1986; 47:545-54.
Background Reference 03
Gentry JJ, Barker, PA, and Carter BD. The p75 neuro-trophin receptor: multiple interactors and numerous functions. Prog. Brain Res. 2004;146:25-39.
Background Reference 04
Nykjaer A, Willnow TE, and Petersen CM. p75NTR - live or let die. Curr. Opin. Neurobio. 2005; 15:49-57.
Other Product Names
NGFR Antibody: CD271, p75NTR, TNFRSF16, p75 (NTR), Gp80-LNGFR, Tumor necrosis factor receptor superfamily member 16, NGF receptor
Tested Applications
ELISA, WB, ICC, IF
Protein ID
4505393
Physical Properties
Liquid

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