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BTK Antibody

CAT: 0223-3395-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3395-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BTK Antibody: Bruton's tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked agamma-globulinaemia, and has since been shown to involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.
NCBI Gene ID
695
Swiss Prot
Q06187
Accession Number
Q06187
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
BTK Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1215 - U937 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
Buffer
BTK Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BTK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Multiple isoforms of BTK are known to exist.
Symbol
BTK
Positive Control 2
Cat. No. 1224 - Daudi Cell Lysate
NCBI Official Name
Bruton agammaglobulinemia tyrosine kinase
NCBI Organism
Homo sapiens
Background Reference 01
Vetrie D, Vorechovsky I, Sideras P, et al. The gene involved in X-linked aγ globulinaemia is a member of the src family of tyrosine kinases. Nature 1993; 361:226-33.
Background Reference 02
Kawakami Y, Kitaura J, Hata D, et al. Functions of Bruton's tyrosine kinase in mast and B cells. J. Leukoc. Biol. 1999; 65 (3) :286-90.
Background Reference 03
Jefferies CA, Doyla S, Brunner C, et al. Bruton's tyrosine kinase is a Toll/Interleukin-1 receptor domain-binding protein that participates in nuclear factor kB activation by Toll-like receptor 4. J. Biol. Chem. 2003; 278:26258-26264.
Background Reference 04
Akira S and Takeda K. Toll-like receptor Signalling. Nat. Rev. Immunol. 2004; 4:499-511.
Other Product Names
BTK Antibody: AT, ATK, BPK, XLA, IMD1, AGMX1, PSCTK1, Tyrosine-protein kinase BTK, Agammaglobulinemia tyrosine kinase
Tested Applications
ELISA, WB, IHC-P, ICC, IF
Protein ID
547759
Physical Properties
Liquid

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