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CIAP Antibody

CAT: 0223-3325-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3325-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
NCBI Gene ID
329
Swiss Prot
Q13490
Accession Number
NP_001157
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3325
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar cIAP expression profile in human, mouse and rat cell lines detected by two independent anti-cIAP antibodies that recognize different epitopes, 3325 against C-terminus domain and competitor antibody against recombinant protein. cIAP proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3325 competitor antibody
Field of Research
Apoptosis, Cancer
Purification
CIAP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1331 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (93%), Chicken: (92%)
Buffer
CIAP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CIAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human cIAP has 2 isoforms, including isoform 1 (618aa, 70kD) and isoform 2 (569aa, 64kD) . Mouse cIAP has one isoform (612aa, 70kD) and Rat cIAP also has one isoform (589aa, 67kD) . 3325 can detect human, mouse and rat.
Symbol
BIRC2
Positive Control 2
Cat. No. 1203 - A549 Cell Lysate
Positive Control 3
Cat. No. 1220 - SK-N-SH Cell Lysate
NCBI Official Name
Baculoviral IAP repeat-containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Schimmer. Cancer Res. 2004; 64:7183-90.
Background Reference 02
Rothe et al. Cell 1995; 83:1243-52.
Background Reference 03
Deveraux et al. EMBO J. 1998; 17:2215-23.
Background Reference 04
Li et al. Nature 2002; 416:345-7.
Citation 01
19906199
Citation 02
22935676
Other Product Names
CIAP Antibody: API1, MIHB, HIAP2, RNF48, cIAP1, Hiap-2, c-IAP1, API1, IAP2, Baculoviral IAP repeat-containing protein 2, C-IAP1, IAP-2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4502141
Physical Properties
Liquid

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