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BRUCE Antibody

CAT: 0223-3309-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3309-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
NCBI Gene ID
57448
Swiss Prot
Q9NR09
Accession Number
NP_057336
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
BRUCE Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 11-801 - Human Small Intestine Tissue Slide
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Buffer
BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BRUCE antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
534 kDa
Fragment
IgG
Specificity
BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.
Symbol
BIRC6
NCBI Official Name
Baculoviral IAP repeat-containing protein 6
NCBI Organism
Homo sapiens
Background Reference 01
Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004; 64:7183-90.
Background Reference 02
Chen Z, Naito M, Hori S, et al. A human IAP-gamily gene, apollon, expressed in human brain cancer cells. Biochem. Biophys. Res. Commun. 1999; 264:847-54
Background Reference 03
Hao Y, Sekine K, Kawabata A, et al. Apollon ubiquitinates SMAC and Caspase-9, and has an essential cytoprotection function. Nat. Cell Biol. 2004; 6:849-60.
Other Product Names
BRUCE Antibody: BRUCE, APOLLON, KIAA1289, Baculoviral IAP repeat-containing protein 6, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE
Tested Applications
ELISA, IHC-P
Protein ID
153792694
Physical Properties
Liquid

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