TRAF6 Antibody

• Background:

  TRAF6 Antibody: Signals from the IL-1 receptor (IL-1R) /Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-κ B. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.

• NCBI Gene ID:

  7189

• Swiss Prot:

  Q9Y4K3

• Accession Number:

  NP_004611

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  TRAF6 Antibody is Ion exchange chromatography purified.

• Positive Control:

  Cat. No. 1216 - PC-3 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (86%), Pig: (92%)

• Buffer:

  TRAF6 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TRAF6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TRAF6

• Positive Control 2:

  Cat. No. 1204 - K562 Cell Lysate

• Positive Control 3:

  Cat. No. 17-004 - K-562 Cell Slide

• NCBI Official Name:

  TNF receptor-associated factor 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

• Background Reference 02:

  Wu H. Assembly of post-receptor signaling complexes for the tumor necrosis factor superfamily. Adv. Protein Chem. 2004; 68:225-79.

• Background Reference 03:

  Wajant H and Scheurich P. Analogies between Drosophila and mammalian TRAF pathways. Prog. Mol. Subcell. Biol. 2004; 34:47-72.

• Background Reference 04:

  Kobayashi T, Walsh PT, Walsh MC, et al. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 2003; 19:353-63.

• Other Product Names:

  TRAF6 Antibody: RNF85, MGC:3310, RNF85, E3 ubiquitin-protein ligase TRAF6

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  4759254

• Physical Properties:

  Liquid