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MCG10 Antibody

CAT: 0223-2479-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2479-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MCG10 Antibody: MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
NCBI Gene ID
57060
Swiss Prot
P57723
Accession Number
EAW65166
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
MCG10 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%), Bovine: (100%)
Buffer
MCG10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MCG10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PCBP4
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Poly (rC) binding protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Makeyev AV and Liebhaber SA. The poly (C) -binding proteins: a multiplicity of functions and a search for mechanisms. RNA2002; 8:265-78.
Background Reference 02
Zhu J and Chen X. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G2-M. Mol. Cell Biol.2000; 20:5602-5618.
Background Reference 03
Pio R, Zudaire I, Pino I, et al. a-CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant aCP-4a, is underexpressed in lung cancer. Cancer Res.2004; 64:4171-9.
Other Product Names
MCG10 Antibody: CBP, LIP4, MCG10Alpha-CP4
Tested Applications
ELISA, WB, ICC, IF
Protein ID
119585570
Physical Properties
Liquid

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