BCMA Antibody

• Background:

  BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-κ B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

• NCBI Gene ID:

  608

• Swiss Prot:

  Q02223

• Accession Number:

  NP_001183

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines, Cancer

• Purification:

  BCMA Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1204 - K562 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  BCMA Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BCMA antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TNFRSF17

• Positive Control 2:

  Cat. No. 1215 - U937 Cell Lysate

• Positive Control 3:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Positive Control 4:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 17

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285:260-3

• Background Reference 02:

  Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 1999; 189:1747-56

• Background Reference 03:

  Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999; 65:680-3

• Background Reference 04:

  Mukhopadhyay A, Ni J, Zhai Y, et al. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J. Biol. Chem. 1999; 274:15978-81

• Other Product Names:

  BCMA Antibody: BCM, BCMA, CD269, TNFRSF13A, BCM, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  23238192

• Physical Properties:

  Liquid