BCMA Antibody

• Background :

  BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-κ B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

• NCBI Gene ID :

  608

• Swiss Prot :

  Q02223

• Accession Number :

  NP_001183

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Chemokines & Cytokines, Cancer

• Purification :

  BCMA Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1204 - K562 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  BCMA Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  BCMA antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  TNFRSF17

• Positive Control 2 :

  Cat. No. 1215 - U937 Cell Lysate

• Positive Control 3 :

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Positive Control 4 :

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name :

  Tumor necrosis factor receptor superfamily, member 17

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285:260-3

• Background Reference 02 :

  Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 1999; 189:1747-56

• Background Reference 03 :

  Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999; 65:680-3

• Background Reference 04 :

  Mukhopadhyay A, Ni J, Zhai Y, et al. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J. Biol. Chem. 1999; 274:15978-81

• Other Product Names :

  BCMA Antibody: BCM, BCMA, CD269, TNFRSF13A, BCM, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  23238192

• Physical Properties :

  Liquid