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BCMA Antibody

CAT: 0223-2397-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2397-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-κ B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
NCBI Gene ID
608
Swiss Prot
Q02223
Accession Number
NP_001183
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines, Cancer
Purification
BCMA Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Buffer
BCMA Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BCMA antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TNFRSF17
Positive Control 2
Cat. No. 1215 - U937 Cell Lysate
Positive Control 3
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 4
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 17
NCBI Organism
Homo sapiens
Background Reference 01
Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285:260-3
Background Reference 02
Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 1999; 189:1747-56
Background Reference 03
Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999; 65:680-3
Background Reference 04
Mukhopadhyay A, Ni J, Zhai Y, et al. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J. Biol. Chem. 1999; 274:15978-81
Other Product Names
BCMA Antibody: BCM, BCMA, CD269, TNFRSF13A, BCM, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
23238192
Physical Properties
Liquid

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