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P53R2 Antibody

CAT: 0223-2383-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2383-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
P53R2 Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
NCBI Gene ID
50484
Swiss Prot
Q7LG56
Accession Number
BAA92434
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
P53R2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Buffer
P53R2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
P53R2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least six isoforms of p53R2 are known to exist; this antibody will detect all but the largest isoform.
Symbol
RRM2B
Positive Control 2
Cat. No. 1212 - 3T3 Cell Lysate
Positive Control 3
Cat. No. 1302 - Human Lung Tissue Lysate
Positive Control 4
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Ribonucleotide reductase M2 B (TP53 inducible)
NCBI Organism
Homo sapiens
Background Reference 01
Tanaka H, Arakawa H, Yamaguchi T, et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 2000; 404:42-9.
Background Reference 02
Matsuoka S, Huang M, and Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998;2 82:1893-7.
Background Reference 03
Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8.
Background Reference 04
Oda K, Arakawa H, Tanaka T, et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 2000; 102:849-62.
Other Product Names
P53R2 Antibody: P53R2, MTDPS8A, MTDPS8B, P53R2, Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53R2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7229086
Physical Properties
Liquid

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