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TP1 Antibody

CAT: 0223-2345-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2345-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1) . Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
NCBI Gene ID
7011
Swiss Prot
Q99973
Accession Number
AAC51107
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
TP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/ml
Buffer
TP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TEP1
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Telomerase-associated protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Greider CW. Telomere length regulation. Annu. Rev. Biochem.1996; 274:92-7.
Background Reference 02
Cong YS, Wright WE, and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev.2002; 66:407-25.
Background Reference 03
Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science1997; 275:973-7.
Background Reference 04
Wong JMY and Collins K. Telomere maintenance and disease. Lancet2003; 362:983-8.
Other Product Names
TP1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, TP1, Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
1848277
Physical Properties
Liquid

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