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IKK gamma Antibody

CAT: 0223-2335-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2335-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IKK gamma Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. The Iκ B kinase (IKKα and IKKβ ) phosphorylates IkB and mediates NF-κ B activation. A novel molecule in the IKK complex was recently identified and termed IKKγ /NEMO/FIP3/IKKAP1. IKKγ interacts with IKKβ and is required for the activation of IKK complex and NF-κ B by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κ B activation.
NCBI Gene ID
8517
Swiss Prot
Q9Y6K9
Accession Number
AF074382
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
IKK gamma Antibody is DEAE purified.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Buffer
IKK gamma Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IKK gamma antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
IgG
Specificity
IKK gamma has no cross response to IKK alpha or IKK beta.
Symbol
IKBKG
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
NCBI Organism
Homo sapiens
Background Reference 01
Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-γ is an essential regulatory subunit of the Iκ B kinase complex. Nature 1998;395 (6699) :297-300
Background Reference 02
Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ, Israel A. Complementation cloning of NEMO, a component of the Iκ B kinase complex essential for NF-κ B activation. Cell. 1998;93 (7) :1231-40.
Background Reference 03
Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS. Identification of a cell protein (FIP-3) as a modulator of NF-κ B activity and as a target of an adenovirus inhibitor of tumor necrosis factor α -induced apoptosis. Proc Natl Acad Sci U S A 1999;96 (3) :1042-7
Background Reference 04
Mercurio F, Murray BW, Shevchenko A, Bennett BL, Young DB, Li JW, Pascual G, Motiwala A, Zhu H, Mann M, Manning AM. Iκ B kinase (IKK) -associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19 (2) :1526-38.
Other Product Names
IKK gamma Antibody: IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, ZC2HC9, IKK-gamma, NF-kappa-B essential modulator
Tested Applications
ELISA, WB, ICC, IF
Protein ID
3641279
Physical Properties
Liquid

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