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FLASH Antibody

CAT: 0223-2271-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2271-01Size:0.02 mg
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Background
FLASH Antibody: A novel mammalian CED-4 homologous was recently identified and cloned in mouse and human and designated FLASH (for FLICE-associated huge protein) . FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. FLASH is widely expressed.
NCBI Gene ID
9994
Swiss Prot
Q9UKL3
Accession Number
AF165161
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
FLASH Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (94%)
Buffer
FLASH Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FLASH antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
220 kDa
Fragment
IgG
Symbol
CASP8AP2
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Caspase 8 associated protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 1999;398:777-85
Background Reference 02
Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM Apoptosis. Searching for FLASH domains. Nature 1999;401:662-3
Background Reference 03
Medema JP. Apoptosis. Life and death in a FLASH. Nature 1999;398:756-7 (WD0800)
Other Product Names
FLASH Antibody: CED-4, FLASH, RIP25, KIAA1315, CASP8-associated protein 2, FLICE-associated huge protein
Tested Applications
ELISA, WB, ICC, IF
Protein ID
5533376
Physical Properties
Liquid

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