SODD Antibody

• Background:

  SODD Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

• NCBI Gene ID:

  9530

• Swiss Prot:

  O95429

• Accession Number:

  AF111116

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  SODD Antibody is DEAE purified.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/ml

• Buffer:

  SODD Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SODD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  IgG

• Symbol:

  BAG4

• Positive Control 2:

  Cat. No. 1208 - THP-1 Cell Lysate

• Positive Control 3:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  BCL2-associated athanogene 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jiang Y, Woronicz JD, Liu W, Goeddel DY. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 1999;283:543-6 (RD1299)

• Other Product Names:

  SODD Antibody: SODD, BAG-4, SODD, BAG family molecular chaperone regulator 4, Bcl-2-associated athanogene 4

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  4160013

• Physical Properties:

  Liquid