RICK Antibody

• Background:

  RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-κ B and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1β . The messenger RNA of RICK is expressed in multiple human tissues.

• NCBI Gene ID:

  8767

• Swiss Prot:

  O43353

• Accession Number:

  O43353

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  RICK Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/ml

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (95%)

• Buffer:

  RICK Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  RICK antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  RIPK2

• Positive Control 2:

  Cat. No. 1225 - Ramos Cell Lysate

• Positive Control 3:

  Cat. No. 1287 - EL4 Cell Lysate

• Positive Control 4:

  Cat. No. 1202 - A431 Cell Lysate

• Positive Control 5:

  Cat. No. 1204 - K562 Cell Lysate

• Positive Control 6:

  Cat. No. 17-002 - A-431 Cell Slide

• NCBI Official Name:

  Receptor-interacting serine-threonine kinase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Inohara N, del Peso L, Koseki T, et al. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem. 1998; 273:12296-300.

• Background Reference 02:

  McCarthy JV, Ni J, and Dixit VM. RIP2 is a novel NF-κ B-activating and cell death-inducing kinase. J. Biol. Chem. 1998; 273:16968-75.

• Background Reference 03:

  Thome M, Hofmann K, Burns K, et al. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol. 1998; 8:885-8.

• Other Product Names:

  RICK Antibody: CCK, RICK, RIP2, CARD3, GIG30, CARDIAK, UNQ277/PRO314/PRO34092, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARD-containing IL-1 beta ICE-kinase

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  20455217

• Physical Properties:

  Liquid