ZIPK Antibody

• Background :

  ZIPK Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.

• NCBI Gene ID :

  1613

• Swiss Prot :

  O43293

• Accession Number :

  BAA81746

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis, Autophagy, Cancer

• Purification :

  ZIPK Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration :

  1 mg/ml

• Buffer :

  ZIPK Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  ZIPK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  DAPK3

• Positive Control 2 :

  Cat. No. 1205 - Jurkat Cell Lysate

• Positive Control 3 :

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Positive Control 4 :

  Cat. No. 1208 - THP-1 Cell Lysate

• Positive Control 5 :

  Cat. No. 17-005 - Jurkat Cell Slide

• NCBI Official Name :

  Death-associated protein kinase 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol 1998;18:1642-51 (RD1299)

• Other Product Names :

  ZIPK Antibody: ZIP, ZIPK, Death-associated protein kinase 3, DAP-like kinase, DAP kinase 3

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  5162884

• Physical Properties :

  Liquid