ZIPK Antibody

• Background:

  ZIPK Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.

• NCBI Gene ID:

  1613

• Swiss Prot:

  O43293

• Accession Number:

  BAA81746

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Autophagy, Cancer

• Purification:

  ZIPK Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/ml

• Buffer:

  ZIPK Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZIPK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  DAPK3

• Positive Control 2:

  Cat. No. 1205 - Jurkat Cell Lysate

• Positive Control 3:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Positive Control 4:

  Cat. No. 1208 - THP-1 Cell Lysate

• Positive Control 5:

  Cat. No. 17-005 - Jurkat Cell Slide

• NCBI Official Name:

  Death-associated protein kinase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol 1998;18:1642-51 (RD1299)

• Other Product Names:

  ZIPK Antibody: ZIP, ZIPK, Death-associated protein kinase 3, DAP-like kinase, DAP kinase 3

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  5162884

• Physical Properties:

  Liquid