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DNase II Antibody

CAT: 0223-2059-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2059-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNase II Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus. DNase II causes both chromatin condensation and DNA fragmentation. The genes encoding human, porcine, and murine DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (alpha) and 12 kDa (beta) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation. DNase II is ubiquitously expressed in human tissues.
NCBI Gene ID
1777
Swiss Prot
O00115
Accession Number
AF047016
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Signal Transduction
Purification
DNase II Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/ml
Buffer
DNase II Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DNase II antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
Aprox: 40 kDa
Fragment
IgG
Symbol
DNASE2
Positive Control 2
Cat. No. 1208 - THP-1 Cell Lysate
Positive Control 3
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Deoxyribonuclease II, lysosomal
NCBI Organism
Homo sapiens
Background Reference 01
Zamzami N, Kroemer G. Condensed matter in cell death. Nature 1999;401:127-8
Background Reference 02
Yasuda T, Takeshita H, Iida R, Nakajima T, Hosomi O, Nakashima Y, Kishi K. Molecular cloning of the cDNA encoding human deoxyribonuclease II. J Biol Chem 1998;273:2610-6
Background Reference 03
Krieser RJ, Eastman A. The cloning and expression of human deoxyribonuclease II. A possible role in apoptosis. J Biol Chem 1998;273:30909-14
Background Reference 04
Shiokawa D, Tanuma S. Cloning of cDNAs encoding porcine and human DNase II. Biochem Biophys Res Commun 1998;247:864-9
Other Product Names
DNase II Antibody: DNL, DNL2, DNASE2A, Deoxyribonuclease-2-alpha, Acid DNase, DNase II alpha
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
2921838
Physical Properties
Liquid

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