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DNase-I Polyclonal Antibody

CAT: 0763-D-AB-10417L-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-D-AB-10417L-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.
Abbreviation
DNase-I
UniProt
P24855
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human DNase-I protein expressed by Mammalian
Target
Deoxyribonuclease-1; Deoxyribonuclease I; DNase I; Dornase alfa; DNASE1; DNL1; DRNI
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
31kDa
Observed Molecular Weight
43kDa
Isotype
IgG

UniProtKB · P24855

Deoxyribonuclease-1

DNAS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24855
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DNASE1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.21.1
Processing
Precursor
Secondary accessions
B4DV35, Q14UU9, Q14UV0
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Molecular function

Actin-bindingEndonucleaseHydrolaseNuclease

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Ligand

Calcium

Cellular component

Cytoplasmic vesicleNucleusSecreted

PTM

Disulfide bondGlycoprotein

Domain

Signal

Disease

Systemic lupus erythematosus

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