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NIK Antibody

CAT: 0223-1129-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-1129-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NIK Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα , LPS and mitogens. A serine/threonine protein kinase which mediates NF-κ B activation by IL-1, TNFα and CD95 was identified recently and designated NIK (for NF-κ B inducing kinase) . NIK is an activator of Iκ B kinase alpha and beta (IKKα and IKKβ ) . Therefore, NIK is a key molecule in the NF-κ B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.
NCBI Gene ID
9020
Swiss Prot
Q99558
Accession Number
Q99558
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
NIK Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (94%)
Buffer
NIK Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NIK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
Predicted: 104 kDa
Fragment
IgG
Symbol
MAP3K14
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 14
NCBI Organism
Homo sapiens
Background Reference 01
Malinin NL, Boldin MP, Kovalenko AV, et al. MAP3K-related kinase involved in NF-κ B induction by TNF, CD95 and IL-1. Nature 1997; 385:540-4.
Background Reference 02
Regnier CH, Song HY, Gao X, et al. Identification and characterization of an Iκ B kinase. Cell 1997; 90:373-83.
Background Reference 03
Woronicz JD, Gao X, Cao Z, et al. Iκ B kinase-β : NF-κ B activation and complex formation with Iκ B kinase-α and NIK. Science 1997; 278:866-9.
Background Reference 04
Ling L, Cao Z, and Goeddel D. NF-κ B-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 1998; 95:3792-7.
Other Product Names
NIK Antibody: HS, NIK, HSNIK, FTDCR1B, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK
Tested Applications
ELISA, WB, IF, ICC
Protein ID
92090612
Physical Properties
Liquid

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