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STAT1 alpha Antibody

CAT: 0223-1021-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-1021-01Size:0.02 mg
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Background
STAT1 alpha Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-α , IFN-β , IFN-γ and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1) .
NCBI Gene ID
6772
Swiss Prot
P42224
Accession Number
NP_009330
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
1021
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar STAT1 alpha expression profile in human cell lines detected by two independent anti-STAT1 alpha antibodies that recognize different epitopes, 1021 against C-terminus domain and competitor antibody against C-terminus domain. STAT1 alpha proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines1021 competitor antibody
Field of Research
Signal Transduction
Purification
STAT1 alpha Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Pig: (94%)
Buffer
STAT1 alpha Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
STAT1 alpha antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of STAT1 are known to exist; this antibody will only recognize the larger isoform.
Isoform
Human STAT1 alpha has two isoforms, including isoform 1 (750aa, 87.3kD) and isoform 2 (712aa, 83kD) . Mouse STAT1 alpha has one isoform (749aa, 87.2kD) and Rat STAT1 alpha also has one isoform (749aa, 87.2kD) . 1021 can detect longer human isoform, mouse and rat, but it cannot detect the shorter human isoform.
Symbol
STAT1
Positive Control 2
Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 3
Cat. No. 1202 - A431 Cell Lysate
Positive Control 4
Cat. No. 1204 - K562 Cell Lysate
Positive Control 5
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Signal transducer and activator of transcription 1, 91kDa
NCBI Organism
Homo sapiens
Background Reference 01
Leonard and O'Shea. Annu. Rev. Immunol. 1998; 16:293-322.
Background Reference 02
Schindler and Darnell. Annu. Rev. Biochem. 1995; 64:621-51.
Background Reference 03
Darnell. Science 1997; 277:1630-5.
Background Reference 04
Schindler et al. Proc. Natl. Acad. Sci. USA 1992; 89:7836-9.
Other Product Names
STAT1 alpha Antibody: CANDF7, ISGF-3, STAT91
Tested Applications
ELISA, WB, ICC, IP, IHC-P, IF
Protein ID
6274552
Physical Properties
Liquid

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