Junctional Adhesion Molecule 1 (F11R) (NM_144504) Human Recombinant Protein

• Background:

  Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

• Synonyms:

  CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; KAT; PAM-1

• Gene ID:

  50848

• UniProt:

  Q9Y624

• Accession Number mRNA:

  NM_144504

• Chromosomal Location:

  1q23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection, Leukocyte transendothelial migration, Tight junction

• Field of Research:

  Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection, Leukocyte transendothelial migration, Tight junction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  29.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  F11R

• Species:

  Human

• Protein ID:

  NP_653087

• Overview:

  Recombinant protein of human F11 receptor (F11R), transcript variant 5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/50848

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y624

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_144504

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_653087