Junctional Adhesion Molecule C (JAM3) (NM_032801) Human Recombinant Protein

• Background:

  Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

• Synonyms:

  JAM-2; JAM-3; JAM-C; JAMC

• Gene ID:

  83700

• UniProt:

  Q9BX67

• Accession Number mRNA:

  NM_032801

• Chromosomal Location:

  11q25

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection, Leukocyte transendothelial migration, Tight junction

• Field of Research:

  Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection, Leukocyte transendothelial migration, Tight junction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  36.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  JAM3

• Species:

  Human

• Protein ID:

  NP_116190

• Overview:

  Recombinant protein of human junctional adhesion molecule 3 (JAM3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/83700

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BX67

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_032801

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_116190