IRE1 (ERN1) (NM_001433) Human Recombinant Protein

• Background:

  This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR) . The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]

• Synonyms:

  HIRE1p; IRE1; IRE1a; IRE1P

• Gene ID:

  2081

• UniProt:

  O75460

• Accession Number mRNA:

  NM_001433

• Chromosomal Location:

  17q23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alzheimer's disease

• Field of Research:

  Alzheimer's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  2762229228416388

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Protein Kinase, Transmembrane

• Molecular Weight:

  109.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ERN1

• Species:

  Human

• Protein ID:

  NP_001424

• Overview:

  Recombinant protein of human endoplasmic reticulum to nucleus signaling 1 (ERN1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2081

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75460

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001433

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001424