B7H3 (CD276) (NM_025240) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

• Synonyms:

  4Ig-B7-H3; B7-H3; B7H3; B7RP-2

• Gene ID:

  80381

• UniProt:

  Q5ZPR3, Q5ZPR3-2

• Accession Number mRNA:

  NM_025240

• Chromosomal Location:

  15q24.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell adhesion molecules (CAMs)

• Field of Research:

  Cell adhesion molecules (CAMs)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  33.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CD276

• Species:

  Human

• Protein ID:

  NP_079516

• Overview:

  Recombinant protein of human CD276 molecule (CD276), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/80381

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q5ZPR3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_025240

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_079516