B7H3 (CD276) Mouse Monoclonal Antibody [Clone ID: LBI1A10]

• Background:

  The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

• Synonyms:

  4Ig-B7-H3; B7-H3; B7H3; B7RP-2

• Gene Name:

  Homo sapiens CD276 molecule (CD276), transcript variant 2, mRNA.

• Gene ID:

  80381

• UniProt:

  Q5ZPR3

• Conjugation:

  Unconjugated

• Related Pathways:

  Cell adhesion molecules (CAMs)

• Field of Research:

  Cell adhesion molecules (CAMs)

• Dilution:

  WB 1:500-1000, FLOW 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  CD276

• Overview:

  Carrier-free (BSA/glycerol-free) CD276 mouse monoclonal antibody, clone LBI1A10

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=80381

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q5ZPR3