H2BC4 (NM_003526) Human Recombinant Protein

• Background:

  Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. The main transcript variant of this gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. This transcript variant lacks a polyA tail but instead contains a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Apr 2020]

• Synonyms:

  DJ221C16.3; H2B.1; H2B/l; H2BC6; H2BC7; H2BC8; H2BC10; H2BFL; HIST1H2BC

• Gene ID:

  8347

• UniProt:

  P62807, B2R4S9

• Accession Number mRNA:

  NM_003526

• Chromosomal Location:

  6p22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Systemic lupus erythematosus

• Field of Research:

  Systemic lupus erythematosus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Stem cell - Pluripotency

• Molecular Weight:

  13.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  H2BC4

• Species:

  Human

• Protein ID:

  NP_003517

• Overview:

  Recombinant protein of human histone cluster 1, H2bc (HIST1H2BC)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8347

• Uniprot URL:

  https://www.uniprot.org/uniprot/P62807

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003526

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003517