NIRF (UHRF2) (NM_152896) Human Recombinant Protein

• Background:

  This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

• Synonyms:

  NIRF; RNF107; TDRD23; URF2

• Gene ID:

  115426

• UniProt:

  Q96PU4

• Accession Number mRNA:

  NM_152896

• Chromosomal Location:

  9p24.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  89.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  UHRF2

• Species:

  Human

• Protein ID:

  NP_690856

• Overview:

  Recombinant protein of human ubiquitin-like with PHD and ring finger domains 2 (UHRF2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/115426

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96PU4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_152896

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_690856