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Gpm6a (BC023461) Mouse Recombinant Protein

CAT: 0882-PM47739M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM47739M5Size:20 µg
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Background
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca (2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs) ; enhances internalization and recycling of mu-type opioid receptor.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse glycoprotein m6a (cDNA clone MGC:32434 IMAGE:5041793), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
MGC38999, M6A
Gene ID
234267
UniProt
P35802
Accession Number mRNA
BC023461
Chromosomal Location
8 B1.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
29.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Gpm6a
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/234267
Uniprot URL
https://www.uniprot.org/uniprot/P35802
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC023461

UniProtKB · P35802

Neuronal membrane glycoprotein M6-a

GPM6A_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P35802
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Gpm6a
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
M6a
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

PTM

AcetylationDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Cellular component

Cell membraneCell projectionMembraneSynapse

Technical term

Direct protein sequencingReference proteome

Biological process

Neurogenesis

Domain

TransmembraneTransmembrane helix

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