Neuronal membrane glycoprotein M6 a (GPM6A) (NM_201591) Human Recombinant Protein

• Background:

  Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca (2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs) ; enhances internalization and recycling of mu-type opioid receptor.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  GPM6; M6A

• Gene ID:

  2823

• UniProt:

  P51674

• Accession Number mRNA:

  NM_201591

• Chromosomal Location:

  4q34.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  31 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GPM6A

• Species:

  Human

• Protein ID:

  NP_963885

• Overview:

  Recombinant protein of human glycoprotein M6A (GPM6A), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2823

• Uniprot URL:

  https://www.uniprot.org/uniprot/P51674

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_201591

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_963885