Tnfsf18 (NM_183391) Mouse Recombinant Protein

• Background:

  Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196) . Regulates T-cell responses (PubMed:14647196) . Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759) . Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614) . Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity) . Promotes leukocyte adhesion to endothelial cells (PubMed:23892569) . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Gitrl; Tnlg2a

• Gene ID:

  240873

• UniProt:

  Q7TS55

• Accession Number mRNA:

  NM_183391

• Chromosomal Location:

  1 69.75 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  19.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Tnfsf18

• Species:

  Mouse

• Protein ID:

  NP_899247

• Overview:

  Purified recombinant protein of Mouse tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/240873

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q7TS55

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_183391

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_899247