A (NM_015770) Mouse Recombinant Protein

• Background:

  Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) . Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  ; As; ASIP; ASP

• Gene ID:

  50518

• UniProt:

  Q03288

• Accession Number mRNA:

  NM_015770

• Chromosomal Location:

  2 76.83 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  14.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  A

• Species:

  Mouse

• Protein ID:

  NP_056585

• Overview:

  Purified recombinant protein of Mouse nonagouti (a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/50518

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q03288

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015770

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_056585