Beta Catenin (CTNNB1) (NM_001904) Human Recombinant Protein

• Background:

  The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

• Synonyms:

  Armadillo; CTNNB; EVR7; MRD19; NEDSDV

• Gene ID:

  1499

• UniProt:

  P35222, A0A024R2Q3

• Accession Number mRNA:

  NM_001904

• Chromosomal Location:

  3p22.1

• Expression System:

  Sf9

• Tag:

  C-DDK

• Related Pathways:

  Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway

• Field of Research:

  Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

• Molecular Weight:

  85 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CTNNB1

• Species:

  Human

• Protein ID:

  NP_001895

• Overview:

  Recombinant protein of human human catenin (cadherin-associated protein), beta 1 (CTNNB1), full length, with C-terminal DDK tag, expressed in sf9 cells

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1499

• Uniprot URL:

  https://www.uniprot.org/uniprot/P35222

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001904

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001895