Catenin, beta (CTNNB1)

• Gene Name:

  [CTNNB1]

• NCBI Gene ID:

  1499

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

• Other Gene Names:

  [CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB]

• Short Name:

  [Catenin, beta (CTNNB1)]

• Other Product Names:

  [catenin beta-1 isoform 1; Catenin beta-1; catenin beta-1; catenin beta 1; Beta-catenin]

• NCBI GI Number:

  148233338

• NCBI Accession Number:

  NP_001091679.1

• NCBI GB Accession Number:

  NM_001098209.1

• Uniprot Accession Number:

  P35222