Catenin, beta (CTNNB1)

CAT: 0544-MBS439892-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
CAT#:0544-MBS439892-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[CTNNB1]
NCBI Gene ID
1499
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 °C.
Antibody without azide - store at -20 to -80 °C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Other Gene Names
[CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB]
Short Name
[Catenin, beta (CTNNB1)]
Other Product Names
[catenin beta-1 isoform 1; Catenin beta-1; catenin beta-1; catenin beta 1; Beta-catenin]
NCBI GI Number
148233338
NCBI Accession Number
NP_001091679.1
NCBI GB Accession Number
NM_001098209.1
Uniprot Accession Number
P35222

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