PSPC1 Rabbit pAb (APR28537N)

CAT: 0882-APR28537N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR28537N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PSPC1 Rabbit pAb (APR28537N) .

Synonyms

PSPC1; PSP1

Gene ID

55269

UniProt

Q8WXF1

Cellular Locus

Cytoplasm, Nucleus, Nucleus matrix, Nucleus speckle, nucleolus

Applications

IP (Mouse ESC) WB (Mus musculus)

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 45kDa/58kDa Observed MW: 65kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55269

Uniprot URL

https://www.uniprot.org/uniprot/Q8WXF1

AA Sequence

MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSF

UniProtKB · Q8WXF1

Paraspeckle component 1

PSPC1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8WXF1
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PSPC1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q5JTQ3, Q8NCZ9, Q8WXE8, Q9NV36

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Molecular function

ActivatorRepressorRNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsImmunityInnate immunityTranscriptionTranscription regulation

Domain

Coiled coilRepeat

Cellular component

CytoplasmNucleus

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