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EXT2 Rabbit pAb (APR24511N)

CAT: 0882-APR24511N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR24511N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EXT2 Rabbit pAb (APR24511N) .
Synonyms
EXT2; SOTV; SSMS
Gene ID
2132
UniProt
Q93063
Cellular Locus
Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass type II membrane protein
Dilution
WB 1:500 - 1:2000 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 82kDa/83kDa/85kDa Observed MW: 82kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2132
Uniprot URL
https://www.uniprot.org/uniprot/Q93063
AA Sequence
PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFD

UniProtKB · Q93063

Exostosin-2

EXT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q93063
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EXT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.4.1.224
Processing
—
Secondary accessions
B2R5Z6, C9JU51, J3KPT2, O15288
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantEpilepsyHereditary multiple exostosesIntellectual disabilityTumor suppressor

PTM

Disulfide bondGlycoprotein

Cellular component

Endoplasmic reticulumGolgi apparatusMembraneSecreted

Molecular function

GlycosyltransferaseTransferase

Ligand

ManganeseMetal-binding

Domain

Signal-anchorTransmembraneTransmembrane helix