ACVR2A Rabbit pAb (APR24519N)

CAT: 0882-APR24519N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR24519N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ACVR2A Rabbit pAb (APR24519N) .

Synonyms

ACVR2A; ACTRII; ACVR2

Gene ID

UniProt

P27037

Cellular Locus

Membrane, Single-pass type I membrane protein

Dilution

WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 45kDa/57kDa Observed MW: 58KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=92

Uniprot URL

https://www.uniprot.org/uniprot/P27037

AA Sequence

AILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNIL

UniProtKB · P27037

Activin receptor type-2A

AVR2A_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P27037
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ACVR2A
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.30
Processing: Precursor
Secondary accessions: B2RAB8, B4DWQ2, D3DP85, Q53TH4, Q6NWV2, Q92474

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumManganeseMetal-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

KinaseReceptorSerine/threonine-protein kinaseTransferase

Domain

SignalTransmembraneTransmembrane helix

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