BRD2 Rabbit pAb (APR24324N)

CAT: 0882-APR24324N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR24324N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BRD2 Rabbit pAb (APR24324N) .

Synonyms

BRD2; BRD2-IT1; D6S113E; FSH; FSRG1; NAT; O27.1.1; RING3; RNF3

Gene ID

6046

UniProt

P25440

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 88kDa Observed MW: 115kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6046

Uniprot URL

https://www.uniprot.org/uniprot/P25440

AA Sequence

Email for sequence

UniProtKB · P25440

Bromodomain-containing protein 2

BRD2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P25440
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BRD2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A2AAU0, B0S7P0, B1AZT1, O00699, O00700, Q15310, Q5STC9, Q63HQ9, Q658Y7, Q6P3U2, Q969U4

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Domain

BromodomainRepeat

Molecular function

Chromatin regulator

Cellular component

ChromosomeNucleus

Biological process

Host-virus interactionTranscriptionTranscription regulation

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