SETD2 Rabbit pAb (APR18632N)

CAT: 0882-APR18632N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR18632N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SETD2 Rabbit pAb (APR18632N) .

Synonyms

SETD2; HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A; LLS; SET2; p231HBP

Gene ID

29072

UniProt

Q9BYW2

Cellular Locus

Chromosome, Nucleus

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 175kDa/192kDa/287kDa Observed MW: 288kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29072

Uniprot URL

https://www.uniprot.org/uniprot/Q9BYW2

AA Sequence

SLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWED

UniProtKB · Q9BYW2

Histone-lysine N-methyltransferase SETD2

SETD2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9BYW2
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SETD2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.1.1.359
Processing: —
Secondary accessions: O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorChromatin regulatorDevelopmental proteinMethyltransferaseTransferase

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseDifferentiationDNA damageDNA repairHost-virus interactionImmunityInnate immunityTranscriptionTranscription regulation

Disease

Autism spectrum disorderDisease variantIntellectual disabilityTumor suppressor

Cellular component

ChromosomeNucleus

Domain

Coiled coil

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingS-adenosyl-L-methionineZinc

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