DNMT3B Rabbit pAb (APR18332N)

CAT: 0882-APR18332N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR18332N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DNMT3B Rabbit pAb (APR18332N) .

Synonyms

DNMT3B; ICF; ICF1; M.HsaIIIB

Gene ID

1789

UniProt

Q9UBC3

Cellular Locus

Nucleus

Applications

WB (Human hepatocellular carcinoma cell line)

Dilution

WB 1:200 - 1:1000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 77-95kDa Observed MW: 96KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1789

Uniprot URL

https://www.uniprot.org/uniprot/Q9UBC3

AA Sequence

MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGM

UniProtKB · Q9UBC3

DNA (cytosine-5)-methyltransferase 3B

DNM3B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9UBC3
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DNMT3B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Dnmt3b
EC number: 2.1.1.37
Processing: —
Secondary accessions: A2A2E2, B4DSM8, B4DSU1, E1P5M6, E1P5M7, E7EN63, E9PBF2, Q9UBD4, Q9UJQ5, Q9UKA6, Q9UNE5, Q9Y5R9, Q9Y5S0

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingMethyltransferaseRepressorTransferase

Coding sequence diversity

Alternative splicing

PTM

CitrullinationIsopeptide bondPhosphoproteinUbl conjugation

Disease

Disease variant

Ligand

Metal-bindingS-adenosyl-L-methionineZinc

Cellular component

Nucleus

Domain

Zinc-finger

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