TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: LBI19B8]

• Background:

  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

• Synonyms:

  Gp145 (trkC) ; TRKC

• Gene Name:

  Homo sapiens neurotrophic receptor tyrosine kinase 3 (NTRK3), transcript variant 3, mRNA.

• Gene ID:

  4916

• UniProt:

  Q16288

• Conjugation:

  Unconjugated

• Related Pathways:

  Neurotrophin signaling pathway

• Field of Research:

  Neurotrophin signaling pathway

• Dilution:

  WB 1:500

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  NTRK3

• Overview:

  Carrier-free (BSA/glycerol-free) NTRK3 mouse monoclonal antibody, clone LBI19B8

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4916

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16288