TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: LBI4E10]

• Background:

  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

• Synonyms:

  GP145-TrkC; TRKC; gp145 (trkC)

• Gene Name:

  Neurotrophic receptor tyrosine kinase 3

• Gene ID:

  4916

• UniProt:

  Q16288

• Conjugation:

  Unconjugated

• Related Pathways:

  Neurotrophin signaling pathway

• Field of Research:

  Neurotrophin signaling pathway

• Concentration:

  0.9 mg/ml

• Dilution:

  WB 1:1000 IHC 1:50 IF 1:100

• Form:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  NTRK3

• Overview:

  Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone LBI4E10

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4916

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16288