TrkC (NTRK3) (NM_001012338) Human Recombinant Protein

• Background:

  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

• Synonyms:

  Gp145 (trkC) ; GP145-TrkC; TRKC

• Gene ID:

  4916

• UniProt:

  Q16288, X5D2R1

• Accession Number mRNA:

  NM_001012338

• Chromosomal Location:

  15q25.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Neurotrophin signaling pathway

• Field of Research:

  Neurotrophin signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  90.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NTRK3

• Species:

  Human

• Protein ID:

  NP_001012338

• Overview:

  Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4916

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16288

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001012338

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001012338