RANTES (CCL5) Mouse Monoclonal Antibody [Clone ID: LBI10G5]

• Background:

  This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul

• Synonyms:

  D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228

• Gene Name:

  Homo sapiens C-C motif chemokine ligand 5 (CCL5), transcript variant 1, mRNA.

• Gene ID:

  6352

• UniProt:

  P13501

• Conjugation:

  Unconjugated

• Related Pathways:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway

• Field of Research:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway

• Dilution:

  WB 1:500

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Secreted Protein, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCL5

• Overview:

  Carrier-free (BSA/glycerol-free) CCL5 mouse monoclonal antibody, clone LBI10G5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=6352

• Uniprot URL:

  https://www.uniprot.org/uniprot/P13501