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Estradiol benzoate

CAT: 0804-HY-B1192-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1192-01Size:500 mg
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Description
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice[1][2][3][4][5].
CAS Number
50-50-0
Product Name Alternative
β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate
UNSPSC
12352005
Hazard Statement
H351, H360
Target
Bcl-2 Family; Estrogen Receptor/ERR; HBV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Estradiol-benzoate.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 3.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(OC(C5=CC=CC=C5)=O)=C4)[C@@]3([H])CC2
Molecular Formula
C25H28O3
Molecular Weight
376.49
Precautions
H351, H360
References & Citations
[1]Zovko M, et al. Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate. Int J Pharm. 2004 Nov 5;285 (1-2) :35-41.|[2]García-Gómez E, et al. Role of sex steroid hormones in bacterial-host interactions. Biomed Res Int. 2013;2013:928290.|[3]Estradiol benzoate|[4]Xu X, et al. Effects of estradiol benzoate on learning-memory behavior and synaptic structure in ovariectomized mice [J]. Life sciences, 2006, 79 (16) : 1553-1560.|[5]Putz O, et al. Neonatal low-and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland [J]. Biology of reproduction, 2001, 65 (5) : 1496-1505.|[6]He J, et al. Identification of Estradiol Benzoate as an Inhibitor of HBx Using Inducible Stably Transfected HepG2 Cells Expressing HiBiT Tagged HBx [J]. Molecules, 2022, 27 (15) : 5000.|[7]Lu D, et al. Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro [J]. Frontiers in Pharmacology, 2022, 13: 841941.|[8]Rao M V, et al. Effect of estradiol benzoate on reproductive organs and fertility in the male rat [J]. European Journal of Obstetrics & Gynecology and Reproductive Biology, 1983, 15 (3) : 189-198.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Bax

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